We are pleased to announce that our latest research has been published online in the journal RNA (January 29, 2026).
The study, authored by Marko Jörg, Marco Kristen, Lukas Walz, Christine Lietz, Max Müller, Sebastian Nathal, Virginie Marchand, Yuri Motorin, Marie-Luise Winz, Mark Helm and Kristina Friedland, introduces Complementary DNA Oligonucleotide Direct In-Gel Quantification (cDINGQ) — a novel and robust method for the precise analysis of tRNA-derived fragments (tRFs).
tRNA fragments are increasingly recognized as important regulators of cellular processes, yet their accurate detection and quantification remain technically challenging due to their short length and extensive chemical modifications.
🔬 Why this matters
The newly developed cDINGQ method enables:
- highly specific detection of defined tRNA fragment species
- direct in-gel quantification using complementary DNA probes
- improved precision and reproducibility
- a streamlined and cost-effective workflow
By providing a reliable and accessible tool for tRNA fragment quantification, cDINGQ opens new opportunities for advancing research in RNA biology, gene regulation, cellular stress responses and disease mechanisms.
🔗 Read the full article here:
https://rnajournal.cshlp.org/content/early/2026/01/29/rna.080749.125.long