Lab Life 23/24

Group Leader
Prof. Dr. Kristina Friedland (Specialist pharmacist for drug information)	E-Mail: kfriedla@uni-mainz.de Phone: 06131/3920337 Curriculum Vitae

Scientific Staff
Dr. Marko Jörg (Pharmacist)	E-Mail: marjoerg@uni-mainz.de Phone: 06131/3923236 Research focus - tRNAs & tRNA fragments & tRNA modifications in pathological aging and neurodegeneration Awards and Distinctions - DGPT prize for best scientific poster presentation 2023 Scientific Affiliations - Deutsche Pharmazeutische Gesellschaft (DPhG) - Member of Society for Neuroscience (SfN) - Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie e.V. (DGPT)

PhD students
Christine Lietz (Pharmacist)	clietz@uni-mainz.de; 06131/3925651
Lukas Walz (Pharmacist)

Technical Staff
Katharina Pauly (MTA)	kpauly@uni-mainz.de; 06131/3928918
Ina Schulz (MTA)	schulzi@uni-mainz.de; 06131/3923274
Lydia Weidenfeller (MTA)	weidenfe@uni-mainz.de; 06131/3929795

Secretary's office
Doris Gebhardt	dogebhar@uni-mainz.de; 06131/3924319

Phips, Master- und Bachelor-Studenten/innen
Julia Brechtel (PhiP)
Sebastian Nathal (HiWi and upcoming PhiP)
Lena-Sophie Wenzek (BSc student) Reuben Bergmann (BSc student)

Latest News

February 2024
Great news! Julia was accepted as a junior member to the Gutenberg Academy Honors Program. Congrats

February 2024
The wintersemester is coming to its end. We had a great time with the students. Hopefully, they will not forget the playlist with a lot of songs which all had something to do with cardiovascular diseases and the risk factors 😉. Next semester we will focus on "disease of the nervous system". This time we will look at the work of artists, actors and musicians suffering from these diseases to make pharmacology a bit more fun. See you all in April!

January 2024
Our paper about the role of a specific mitochondrial mRNA modification to regulate mitochondrial function under physiological conditions and in Alzheimer disease was accepted to Molecular Psychiatry! This was a great collaborative effort mainly with the Helm group but also others such as the Motorin, Endres, Gerber, Rossmanith and Methner group. Thanks to Marko and Johanna and all involved scientists for their great work!

https://www.nature.com/articles/s41380-024-02421-y

September 2023
Together with Prof. Albena Dinkova-Kostova from the University of Dundee, we received funding from the Scotland-RLP Life Science Research Alliance. One of Albenas PhD students, Miro Novak, will investigate the effects of novel NRF-2 ligands in the Friedland lab. We are looking forward to this collaboration starting in January 2024. Check out Albenas paper in Nature Reviews Drug Discovery about the therapeutical potential of NRF-2 ligands.

https://pubmed.ncbi.nlm.nih.gov/30610225/

September 2023
Marko was selected to give a short talk at the DphG meeting in Tübingen about tRNA modifications in aging and Alzheimer's disease. Congrats!

September 2023
Welcome to our new bachelor students Lena, Reuben and Sophia! Arso just completed her Bachelor thesis.

September 2023
Welcome to our placement student Julia Brechtel. She will continue with her PhD thesis coming back in January after her 3. state examination.

July 2023
New review "Talk to Me—Interplay between Mitochondria and Microbiota in Aging" together with Kristina Endres from the Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University out.

https://www.mdpi.com/1422-0067/24/13/10818

July 2023
Check our our new collaborative work with the Plietker group at TU Dresden about the type-B polyprenylated polycyclic acylphloroglucinol PPAP53 and its effect on TRPC6 channels. This paper features a new AI based TRPC6 protein structure prediction visualizing binding of hyperforin and PPAPs to TRPC6.

https://chemrxiv.org/engage/chemrxiv/article-details/6479b01fe64f843f41322645

June 2023
STIPEND from the Dr. Hilmer Stiftung for our new PhD student Lukas Walz.

May 2023
DGPT Poster prize for Marko Jörg & Christine Lietz